In the US, cigarette smoking is the
leading preventable cause of death
1. 2017 NYT/CDC 2. NYT 1/6/2017. 3. NIDA Opioid Crisis webpage.
There is a clear unmet need for better treatments and for greater treatment utilization, with a large opportunity for safe and effective pharmacotherapy to treat substance abuse and addiction
“Substance abuse is a national public health crisis that robs the United States of its most valuable asset - its people” – 2016 Surgeon General Report
“FDA intends to provide a framework for the development of novel clinical endpoints that can form the basis of product approvals. For example, one endpoint that’s relevant to the treatment of addiction is the craving that fuels continued drug use.”
– 2017, FDA Commissioner Scott Gottlieb, M.D.
In 2016, >50K US deaths due to opioid overdose - more than peak year HIV1
While also in the US...
17M people with Alcohol Use Disorder (AUD)
3M people use Cocaine